Substituted tetrahydroisochinolines as MMP inhibitors, related production method and use as medicine

US7858619B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Armin Hofmeister · Frankfurt, DE
• Manfred Schudok · Eppstein, DE
• Hans Matter · Langenselbold, DE
• Kristin Breitschopf · Frankfurt am Main, DE
• Antonio Ugolini · Le Pecq, FR

Key dates

• Filing date: Sep 27, 2007
• Grant date: Dec 28, 2010
• Expiry date: Jun 19, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a compound of formula (I),wherein R1, R2, R3, R4, A, L and n are as defined herein, its pharmaceutical composition, preparation and uses as a MMP inhibitor.