Diaminopyrimidines as P2X3 and P2X2/3 antagonists

US7858632B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Chris Allen Broka · Foster City, US
• David Scott Carter · Sunnyvale, US
• Michael Patrick Dillon · Mill Valley, US
• Ronald Charles Hawley · Oakland, US
• Alam Jahangir · San Jose, US
• Clara Jeou Jen Lin · Palo Alto, US
• Daniel Warren Parish · Sunnyvale, US

Key dates

• Filing date: Mar 3, 2005
• Grant date: Dec 28, 2010
• Expiry date: Jul 15, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/506
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.