Patent · US Active

Amorphous 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt and process for the preparation thereof

US7858634B2 · kind B2 · utility

0Cited by

9References

16Claims

0Family size

Assignee

CHEMI S.P.A. · IT

Inventors

Stefano Turchetta · Roma, IT
Pietro Massardo · Milano, IT
Umberto Ciambecchini · Roma, IT

Key dates

Filing date	Feb 28, 2005
Grant date	Dec 28, 2010
Priority date	—
Expiry date	Mar 29, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/58
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the preparation of 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt of formulain an amorphous form, preferably lyophilized, and its pharmaceutical compositions are described. Said amorphous form, characterized by stability and simplicity of preparation and formulation, can be obtained by an industrially applicable lyophilization process, which comprises the steps of:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.