Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

US7858643B2 · kind B2 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Jingrong Jean Cui · San Diego, US
• Lee Andrew Funk · Oceanside, US
• Lei Jia · Palo Alto, US
• Pei-Pei Kung · San Diego, US
• Jerry Jialun Meng · San Diego, US
• Mitchell David Nambu · San Diego, US
• Mason Alan Pairish · San Diego, US
• Hong Shen · Shanghai, CN
• Michelle Tran-Dube · Village of La Jolla, US

Key dates

• Filing date: Aug 26, 2005
• Grant date: Dec 28, 2010
• Expiry date: Oct 8, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Enantiomerically pure compound of formula 1are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.