EP4 receptor antagonists

US7858644B2 · kind B2 · utility

Assignee

• Asterand UK Limited · GB

Inventors

• Alexander W. Oxford · Royston, GB
• Richard Jon Davis · Royston, GB
• Robert Alexander Coleman · Royston, GB
• Kenneth Lyle Clark · Hertford, GB
• David Edward Clark · Harlow, GB
• Neil Victor Harris · Tilbury, GB
• Garry Fenton · Harlow, GB
• George Hynd · Harlow, GB
• Keith Alfred James Stuttle · Witham, GB
• Jonathan Mark Sutton · Harlow, GB
• Christopher Newton · Harlow, GB

Key dates

• Filing date: Jan 28, 2009
• Grant date: Dec 28, 2010
• Expiry date: Jun 18, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I):wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: or wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl;