1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof
US7858761B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jun 21, 2005 |
| Grant date | Dec 28, 2010 |
| Priority date | — |
| Expiry date | Mar 5, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H3/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple procedure such as recrystallization, and therefore, it can be advantageously used as an intermediate in the preparation of gemcitabine in a large scale. Further, the 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) can be prepared with high stereoselectivity using the compound of formula (V) as an intermediate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.