Synthesis of 5-azacytidine
US7858774B2 · kind B2 · utility
29Cited by
10References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 10, 2008 |
| Grant date | Dec 28, 2010 |
| Priority date | — |
| Expiry date | Sep 10, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure:The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.