Production of 2′-deoxynucleosides and 2′-deoxynucleoside precursors from 2-dehydro-3-deoxy-D-gluconate

US7858775B2 · kind B2 · utility

Assignees

• RHODIA CHIMIE · FR
• Evologic S.A., Marliere Technologies Societe Civile · FR
• Philippe Marliere · FR

Inventors

• Volker Doring · Stuttgart, DE
• Denis Thibaut · Paris, FR
• Annett Kreimeyer · Combs-la-Ville, FR
• Philippe Marliere · Paris, FR

Key dates

• Filing date: Jun 24, 2004
• Grant date: Dec 28, 2010
• Expiry date: Dec 1, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/42
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This invention relates to a process for preparing 2′-deoxynucleoside compounds or 2′-deoxynucleoside precursors using 2-dehydro-3-deoxy-D-gluconic acid (usually abbreviated as KDG) or its salts as a starting material. A variety of 2′-deoxynucleosides and their analogues are used as a starting material for synthesis or drug formulation in production of an antiviral, anticancer or antisense agent.