Methods for decreasing immune response and treating immune conditions
US7862812B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 6, 2007 |
| Grant date | Jan 4, 2011 |
| Priority date | — |
| Expiry date | Jun 1, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for decreasing an immune response in an animal comprising administering to said animal an agent that binds a bioactive lipid and reduces the effective concentration of said bioactive lipid. Also provided are methods for treating diseases or conditions, including autoimmune disorders, which are characterized by an aberrant, excessive or undesired immune response. The methods of the invention utilize agents that bind bioactive lipids and are capable of decreasing the effective concentration of the bioactive lipid. In some embodiments, the agent is a monoclonal antibody that is reactive against sphingosine-1-phosphate (S1P) or lysophosphatidic acid (LPA).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.