Compositions for down-regulation of CCR5 expression and methods of use thereof
US7863242B2 · kind B2 · utility
1Cited by
5References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 16, 2005 |
| Grant date | Jan 4, 2011 |
| Priority date | — |
| Expiry date | Sep 19, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.