Substituted 2-pyridone derivatives, method for their preparation and their use as medicament

US7863280B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Stefan Peukert · Frankfurt am Main, DE
• Stefan Guessregen · Frankfurt am Main, DE
• Armin Hofmeister · Frankfurt, DE
• Herman Schreuder · Frankfurt am Main, DE
• Uwe Schwahn · Frankfurt am Main, DE

Key dates

• Filing date: Apr 11, 2007
• Grant date: Jan 4, 2011
• Expiry date: Sep 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula (I),wherein R1 and R3 independently represent fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; R2 represents hydrogen, fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; X represents O, S, NH or N(C1-C3-alkyl); and Ar represents an unsubstituted or at least monosubstituted aryl or heteroaryl. Said compounds are inhibitors of poly(ADP-ribose) polymerase (PARP), and may be used for the treatment of a variety of disorders.