4-aminopyrrolopyrimidines as kinase inhibitors
US7863444B2 · kind B2 · utility
26Cited by
28References
11Claims
0Family size
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Key dates
| Filing date | Sep 17, 1999 |
| Grant date | Jan 4, 2011 |
| Priority date | — |
| Expiry date | Sep 17, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chemical compounds having structural formula Iand physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disase states where angiogenesis or endothelial cell hyperproliferaton is a factor. These compounds can be used to treat cancer, hyperproliferative disorders, rheumatoid artheritis, disorders of the immune system, transplant rejection, and inflammatory disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.