Heterocycles

US7863446B2 · kind B2 · utility

Assignee

• Orchid Research Laboratories Limited · IN

Inventors

• Akella Satya Surya Visweswara Srinivas · Chennai, IN
• Ravikumar Tadiparthi · Aurangabad, IN
• Ganapavarapu Veera Raghava Sharma · Visakhapatnam, IN
• Sappanimuthu Thirunavukkarasu · Chennai, IN
• Durairaj Peter Bhakiaraj · Chennai, IN
• Virendra Kachhadia · Chennai, IN
• Kilambi Narsimhan · Chennai, IN
• Sathya Narayana Thara · Chennai, IN
• Sriram Rajagopal · Darsi, IN
• Gaddam Om Reddy · Hyderabad, IN
• Sukunath Narayanan · Chennai, IN
• Venkatesan Parameswaran · Chennai, IN
• Venkatesan Janarthanam · Chennai, IN
• Maruthikumar Narayanam · Chennai, IN
• Sathyanarayana Gadde · Aurangabad, IN
• Uma Ramachandran · Chennai, IN

Key dates

• Filing date: Feb 8, 2008
• Grant date: Jan 4, 2011
• Expiry date: Feb 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.