Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses

US7863450B2 · kind B2 · utility

Assignee

• UCB PHARMA S.A. · BE

Inventors

• Sylvain Celanire · Geneva, CH
• Patrice Talaga · Brussels, BE
• Regorius Leurs · Amsterdam, NL
• Frederic Denonne · Brussels, BE
• Henkdrik Timmerman · Oegstgeest, NL
• Florence Lebon · Braine-l'Alleud, BE

Key dates

• Filing date: Mar 29, 2006
• Grant date: Jan 4, 2011
• Expiry date: Jan 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(CH3) or N; R1 is hydrogen or halogen; R2 is (II); A2 is O or S; R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl or —O—(CH2)n-NR12aR each CH2 in —O—(CH2)n-NR12aR12b being optionally substituted by one or two C1-4 alkyl; R5 is hydrogen or —O—(CH2)m—NR13aR13b, each CH2 in —O—(CH2)m—NR13aR13b being optionally substituted by one or two C1-4 alkyl, and at least one of R4 and R5 should be a —O—(CH2)n-NR12/13aR12/13b group.