Process for the purification of ropinirole hydrochloride
US7863462B2 · kind B2 · utility
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Key dates
| Filing date | Mar 21, 2007 |
| Grant date | Jan 4, 2011 |
| Priority date | — |
| Expiry date | Jan 11, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.