Target-specific compomers and methods of use

US7867714B2 · kind B2 · utility

Assignee

• Sequenom, Inc. · US

Inventors

• Mathias Ehrich · San Diego, US
• Dirk Johannes Van Den Boom · Dreieich, DE

Key dates

• Filing date: Jun 22, 2009
• Grant date: Jan 11, 2011
• Expiry date: Jun 22, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2458/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided herein are libraries of nucleic acid species each comprising a transcription unit having a promoter region operatively linked to a coding sequence. The coding sequence of each nucleic acid species encodes a RNA cleavage substrate comprising a unique compomer species and a cleavage site. Each compomer species has a molecular mass distinguishable from the molecular mass of other compomer species in the library, and cleavage at a cleavage site releases a polynucleotide comprising the compomer species from the RNA cleavage substrate.