Patent · US Active

Methods for determining conformational changes and self-assembly of proteins

US7867718B2 · kind B2 · utility

4Cited by

3References

14Claims

0Family size

Assignee

BioChromix AB · SE

Inventors

Peter Nilsson · Stuvsta-Snättringe, SE
Anna Herland · Linköping, SE
Per Hammarstrom · Linköping, SE
Peter Asberg · Linköping, SE
Olle Inganas · Linköping, SE

Key dates

Filing date	Feb 22, 2005
Grant date	Jan 11, 2011
Priority date	—
Expiry date	Sep 23, 2026

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/68
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.