Substituted 4-phenyltetrahydroisoquinolines, pharmaceutical compositions comprising them and therapeutic methods for their use

US7868003B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Uwe Heinelt · Wiesbaden, DE
• Hans-Jochen Lang · Hofheim, DE
• Klaus Wirth · Frankfurt am Main, DE
• Thomas Licher · Bad Soden, DE
• Armin Hofmeister · Frankfurt, DE

Key dates

• Filing date: Jul 11, 2007
• Grant date: Jan 11, 2011
• Expiry date: May 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted 4-phenyltetrahydroisoquinolines of formula Iwherein R1-R8, N, W, X and Z are defined herein. These compounds and pharmaceutical compositions comprising them are useful in the treatment of respiratory disorders, sleep apnea, kidney disorders, high blood pressure, hypertension, disorders of the central nervous system and the like.