Patent · US Active

2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)

US7868022B2 · kind B2 · utility

2Cited by

20References

15Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Ellen W. Baxter · Glenside, US
Allen B. Reitz · Lansdale, US
Umar Saibu Mohomed Maharoof · North Wales, US
Yifang Huang · Cheltenham, US
Christopher J. Creighton · San Diego, US
Charles H. Reynolds · Austin, US
Chi Luo · Lansdale, US
Brett A. Tounge · Blue Bell, US
Tina Morgan Ross · Limerick, US
Tianbao Lu · Collegeville, US

Key dates

Filing date	Feb 6, 2007
Grant date	Jan 11, 2011
Priority date	—
Expiry date	Aug 22, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.