Modulation of negative immune regulators and applications for immunotherapy
US7868159B2 · kind B2 · utility
0Cited by
21References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 2006 |
| Grant date | Jan 11, 2011 |
| Priority date | — |
| Expiry date | Jan 9, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.