5-heteroaryl thiazoles and their use as PI3K inhibitors

US7868188B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Malena Bengtsson · Lund, SE
• Joakim Larsson · Mörarp, SE
• Grigorios Nikitidis · Lund, SE
• Peter Storm · Timrå, SE
• John Peter Bailey · Macclesfield, GB
• Edward Jolyon Griffen · Macclesfield, GB
• Jean-Claude Arnould · Verrières-le-Buisson, FR
• Thomas G. C. Bird · Reims, FR

Key dates

• Filing date: Nov 7, 2005
• Grant date: Jan 11, 2011
• Expiry date: Mar 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.