Preparation of glycerol derivatives and intermediates therefor
US7868196B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 18, 2006 |
| Grant date | Jan 11, 2011 |
| Priority date | — |
| Expiry date | Aug 29, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC11C3/04
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.