Structure-based modulators of B1 G-protein coupled receptors
US7869958B2 · kind B2 · utility
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21References
7Claims
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Key dates
| Filing date | Aug 9, 2005 |
| Grant date | Jan 11, 2011 |
| Priority date | — |
| Expiry date | Jan 8, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.