Optimized probe selection method
US7869959B2 · kind B2 · utility
1Cited by
2References
7Claims
0Family size
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Key dates
| Filing date | Feb 3, 2006 |
| Grant date | Jan 11, 2011 |
| Priority date | — |
| Expiry date | May 4, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B25/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.