Membranes with controlled permeability to polar and apolar molecules in solution and methods of making same

US7871456B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• David A. Gough · Irvine, US
• Joseph Y. Lucisano · Village of La Jolla, US
• Joe Lin · Taipei, TW
• Hwai-Min Tsay · San Diego, US
• Drahoslav Lim · San Diego, US

Key dates

• Filing date: Aug 10, 2006
• Grant date: Jan 18, 2011
• Expiry date: May 15, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D2325/38
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A membrane for use in an implantable glucose sensor including at least one crosslinked substantially hydrophobic polymer and at least one crosslinked substantially hydrophilic polymer; wherein the first and second polymers are different polymers and substantially form an interpenetrating polymer network, semi-interpenetrating polymer network, polymer blend, or copolymer. The membranes are generally characterized by providing a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). Three methods of making membranes from hydrophobic and hydrophilic monomers formed into polymer networks are provided, wherein according to at least two of the methods, the monomers may be substantially immiscible with one another.