Compositions and methods relating to anti IGF-1 receptor antibodies

US7871611B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Frank J. Calzone · Westlake Village, US
• Rajendra V. Deshpande · Camarillo, US
• Mei-Mei Tsai · Taipei, TW

Key dates

• Filing date: Dec 20, 2005
• Grant date: Jan 18, 2011
• Expiry date: Nov 2, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.