Hepatocyte-targeting vehicle for delivery of glargine insulin to a mammal
US7871641B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 20, 2006 |
| Grant date | Jan 18, 2011 |
| Priority date | — |
| Expiry date | Apr 15, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free glargine insulin and glargine insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Glargine insulin is present within the complex in at least one form wherein the glargine insulin has a positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.