Beta-Secretase modulators and methods of use
US7872009B2 · kind B2 · utility
Assignee
Inventors
- Brian K. Albrecht
- Denise Andersen
- Michael D. Bartberger
- James Brown
- Ryan Brown
- Stuart C. Chaffee
- Yuan Cheng
- Michael Croghan
- Russell Graceffa
- Scott Harried
- Stephen Hitchcock
- Randall W. Hungate
- Ted Judd
- Matthew Kaller
- Charles Kreiman
- Daniel La
- Patricia Lopez
- Craig E. Masse
- Holger Monenschein
- Thomas Nguyen
- Thomas Nixey
- Vinod F. Patel
- Lewis D. Pennington
- Matthew Weiss
- Qiufen Xue
- Bryant Yang
- Wenge Zhong
Key dates
| Filing date | Nov 14, 2006 |
| Grant date | Jan 18, 2011 |
| Priority date | — |
| Expiry date | Dec 26, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Iwherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.