Modulators of the orphan G protein-coupled receptors GPR78 and GPR26
US7872101B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 3, 2007 |
| Grant date | Jan 18, 2011 |
| Priority date | — |
| Expiry date | Jul 25, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/723
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to the use of the interaction between the GPR78 polypeptide or the GPR26 polypeptide and their identified ligands and antagonists as the basis for screening methods for the identification of agents that modulate the activity of these receptors, and for diagnostic and therapeutic purposes. The agents identified by the screening methods of the invention have use in the treatment of GPR78- and/or GPR26-mediated disorders, including, but not limited to, neurological disorders (such as anxiety disorders), metabolic disorders, cardiovascular disorders, hormone-related disorders, vascular disorders and hyperproliferative disorders (such as cancer).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.