Patent · US Active

Process for the removal of exocyclic base protecting groups

US7872121B2 · kind B2 · utility

0Cited by

3References

9Claims

0Family size

Assignee

Avecia Biotechnology, Inc. · US

Inventors

Nanda Sinha · Boxboro, US
Satya Kuchimanchi · Cambridge, US

Key dates

Filing date	Apr 15, 2005
Grant date	Jan 18, 2011
Priority date	—
Expiry date	May 15, 2028

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Nitrogen-protecting groups are removed from the exocyclic nucleobase portion of a 2′-O protected nucleotide or 2′-halo nucleotide by contacting the nucleotide with an inorganic base. Typical is the removal of t-butylphenoxyacetyl protecting groups from the nucleobase portion of a 2′-O protected nucleotide on which the 2′-O protecting group is t-butyldimethylsilyl, removal or deprotection being accomplished by contact with a potassium carbonate solution.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.