Size-selective hemoperfusion polymeric adsorbents
US7875182B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 20, 2006 |
| Grant date | Jan 25, 2011 |
| Priority date | — |
| Expiry date | Nov 20, 2026 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/34
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.