Methods of manufacturing and modifying taxane coatings for implantable medical devices

US7875284B2 · kind B2 · utility

Assignees

• Cook Regentec LLC · US
• MED Institute Inc. · US

Inventors

• Priscilla Reyes · Duncan, US
• William F. Moore · Catlettsburg, US
• Randy Joe Myers · Bloomington, US
• Patrick H. Ruane · Dublin, US
• Melinda S. Morrell · Vienna, US

Key dates

• Filing date: Jun 27, 2007
• Grant date: Jan 25, 2011
• Expiry date: Jan 28, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2250/0091
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.