Compositions of less immunogenic and long-circulating protein-lipid complexes

US7875289B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Sathy Balu-Iyer · Amherst, US
• Robert Straubinger · Amherst, US
• Razvan Miclea · Simi Valley, US
• Aaron Peng · Amherst, US

Key dates

• Filing date: Mar 30, 2007
• Grant date: Jan 25, 2011
• Expiry date: Sep 21, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.