Patent · US Active

Oligonucleotide non-viral delivery systems

US7875449B2 · kind B2 · utility

0Cited by

2References

11Claims

0Family size

Assignee

FMC Biopolymer AS · NO

Inventors

Per Artursson · Uppsala, SE
Mohamed Mahmoud Issa · Uppsala, SE
Sabina Prochazkova Strand · Trondheim, NO
Kjell Morten Varum · Trondheim, NO

Key dates

Filing date	Sep 14, 2007
Grant date	Jan 25, 2011
Priority date	—
Expiry date	Nov 30, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Low molecular weight low molecular weight chitosan oligomers were able to self-assemble siRNA into nanosized particles, provide protection against enzymatic degradation, and mediate gene silencing that is stable over a long period of time in vitro. The control of structural variables in formulating complexes of siRNA with low molecular weight chitosans provides an efficient alternative delivery system for siRNA in vitro and in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.