Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors

US7875621B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Marcel Jozef Maria Van der Aa · Kasterlee, BE
• Albertus Henricus Maria Theresia Van Heertum · Turnhout, BE
• Jacobus Alphonsus Josephus Van Dun · Kasterlee, BE
• Maria Victorina Francisca Somers · Vosselaar, BE
• Walter Boudewijin Leopold Wouters · Kapellen, BE

Key dates

• Filing date: Jun 28, 2005
• Grant date: Jan 25, 2011
• Expiry date: Jan 22, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions containing compounds of formula (I)wherein R1, R3, L, X, Y and Z have defined meanings.