Disaccharides for drug discovery

US7875707B2 · kind B2 · utility

Assignee

• Alchemia Limited · US

Inventors

• Wim Meutermans · Brisbane, AU
• Michael L. West · Brisbane, AU
• George Adamson · Yateley, GB
• Giang Thanh Le · Cleveland, AU
• Nicholas B. Drinnan · Bamaga, AU
• Giovanni Abbenante · Caboolture, AU
• Bernd Becker · Bad Endbach, DE
• Matthias Grathwohl · Konstanz, DE
• Premraj Rajaratnam · Miles, AU
• Gerald Tometzki · Forsayth, AU

Key dates

• Filing date: Apr 24, 2003
• Grant date: Jan 25, 2011
• Expiry date: Apr 24, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B50/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.