Nucleic acids encoding platelet derived growth factor receptor alpha (PDGFRA) activating mutations

US7875710B2 · kind B2 · utility

Assignees

• Oregon Health & Science University · US
• DEPARTMENT OF VETERANS AFFAIRS · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Michael Heinrich · Lake Oswego, US
• Christopher C. Corless · Portland, US
• Jonathan A. Fletcher · Brookline, US
• George D. Demetri · Brookline, US

Key dates

• Filing date: May 14, 2009
• Grant date: Jan 25, 2011
• Expiry date: May 14, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.