Process for manufacture of racemic Carvedilol

US7875730B2 · kind B2 · utility

Assignee

• Cadila Healthcare Ltd. · IN

Inventors

• Dhiraj R. Shah · Sayla, IN
• Ashish Naik · Piscataway, US
• Parva Yogeshchandra Purohit · Sayla, IN
• Rajivkumar Sharma · Sayla, IN
• Virendra Kumar Agarwal · Ahmedabad, IN

Key dates

• Filing date: Feb 22, 2005
• Grant date: Jan 25, 2011
• Expiry date: Mar 3, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/88
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5%) having individual impurity less than 0.1%. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.