Compositions and methods for use for antibodies against sclerostin

US7879322B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Michaela Kneissel · Basel, CH
• Christine Halleux · Dornach, CH
• Shou-Ih Hu · Cambridge, US
• Beate Diefenbach-Streiber · Windach, DE
• Josef Prassler · Germering, DE

Key dates

• Filing date: Oct 10, 2008
• Grant date: Feb 1, 2011
• Expiry date: Oct 10, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/108
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.