Patent · US Active

Methods of treatment involving the protease for activating clotting factor VII

US7879803B2 · kind B2 · utility

0Cited by

7References

13Claims

0Family size

Assignee

CSL Behring AG · DE

Inventors

Jürgen Römisch · Marburg, DE
Annette Feussner · Marburg, DE
Hans-Arnold Stohr · Wetter, DE

Key dates

Filing date	Nov 13, 2007
Grant date	Feb 1, 2011
Priority date	—
Expiry date	Jul 28, 2028

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/96447
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This application describes methods of treatment involving a protease for activating the blood clotting factor VII, which (a) activates blood clotting factor VII, (b) is inhibited by the presence of aprotinin, (c) is increased in its activity by the presence of at least one of the following: calcium ions, heparin, or heparin related substances, and (d) in SDS-PAGE, on subsequent staining in the non-reduced state, has one or more bands in the molecular weight range from 50 to 75 kDa, and in the reduced state has a band at 40 to 55 kDa and one or more bands in the molecular weight range from 10 to 35 kDa, and a band, which corresponds to a proenzyme, in the molecular weight range from 60 to 65 kDa.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.