Agents for preventing and treating disorders involving modulation of the RyR receptors

US7879840B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andrew Marks · Larchmont, US
• Donald W. Landry · New York, US
• Shixian Deng · White Plains, US

Key dates

• Filing date: Aug 17, 2006
• Grant date: Feb 1, 2011
• Expiry date: Jun 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula Iand salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.