4,6-disubstituted pyrimidines and their use as protein kinase inhibitors

US7879853B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Josef Stadlwieser · Konstanz, DE
• Thomas Baer · Edgerton, US
• Thomas Maier · Stockach, DE
• Thomas Beckers · Konstanz, DE
• Thomas Ciossek · Oebisfelde, DE
• Armin Zuelch · Konstanz, DE
• Ulrich Graedler · Weinheim, DE

Key dates

• Filing date: Jun 28, 2005
• Grant date: Feb 1, 2011
• Expiry date: Aug 17, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel pyrimidine derivatives of Formula (1)which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt.