6-substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors

US7879857B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Dominique Jean-Pierre Mabire · La Saussaye, FR
• Jérôme Emile Georges Guillemont · Andé, FR
• Jacobus Alphonsus Josephus Van Dun · Kasterlee, BE
• Maria Victorina Francisca Somers · Vosselaar, BE
• Walter Boudewijn Leopold Wouters · Kapellen, BE

Key dates

• Filing date: Nov 18, 2004
• Grant date: Feb 1, 2011
• Expiry date: Jun 29, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I)wherein n, R1, R2, R3, R4 and X have defined meanings.