Combi-molecules having EGFR and DNA targeting properties
US7879861B2 · kind B2 · utility
1Cited by
1References
6Claims
0Family size
Inventors
Key dates
| Filing date | Jun 14, 2005 |
| Grant date | Feb 1, 2011 |
| Priority date | — |
| Expiry date | Feb 24, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of new chemical agents that demonstrate anti-tumor activity are described. The new chemical agents combine two major mechanisms of anti-tumor action. In an embodiment, the agents are capable of both inhibiting EGFR and damaging DNA while also, upon degradation, degrading to an inhibitor of EGFR and to an agent capable of damaging DNA. Moreover, a novel series of molecules capable of releasing two moles of EGFR inhibitor and a potent bi-functional alkylating agent are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.