Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes

US7879864B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Karl Schoenafinger · Alzenau, DE
• Gerhard Jaehne · Frankfurt, DE
• Elisabeth Defossa · Idstein, DE
• Christian Buning · Frankfurt am Main, DE
• Georg Tschank · Frankfurt am Main, DE
• Ulrich Werner · Frankfurt am Main, DE

Key dates

• Filing date: Feb 13, 2007
• Grant date: Feb 1, 2011
• Expiry date: Dec 7, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives:wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.