Substituted aniline derivatives useful as histamine H3 antagonists

US7879880B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Daniel M. Solomon · Edison, US
• Robert G. Aslanian · Rockaway, US
• Michael Y. Berlin · Flemington, US
• Manuel de Lera Ruiz · Readington, US
• Kevin D. McCormick · Berkeley Heights, US
• Mwangi W. Mutahi · Orange, US
• Wing C. Tom · Cedar Grove, US

Key dates

• Filing date: Dec 19, 2006
• Grant date: Feb 1, 2011
• Expiry date: May 27, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the formulaor a pharmaceutically acceptable salt thereof, wherein M2 is N; X is a bond, optionally substituted alkylene, alkenylene, —O—, —CH2N(R12)—, —N(R12)CH2—, —N(R12)—, —NHC(O)—, —OCH2—, —CH2O—, or —S(O)0-2—; and Y is —(CH2)1-2—, —C(═O)—, —C(═NOR13)— or —SO0-2—;