Protein kinase modulators and method of use

US7880000B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Stephanie Geuns-Meyer · Medford, US
• Brian L. Hodous · Cambridge, US
• Stuart C. Chaffee · Philadelphia, US
• Paul Tempest · Somerville, US
• Philip R. Olivieri · Boston, US
• Rebecca Elizabeth Johnson · Arlington, US
• Brian K. Albrecht · Cambridge, US
• Vinod F. Patel · Acton, US
• Victor J. Cee · Thousand Oaks, US
• Joseph L. Kim · Wayland, US
• Steven Bellon · Wellesley, US
• Xiaotian Zhu · Newton, US
• Yuan Cheng · Newbury Park, US
• Ning Xi · Newbury Park, US
• Karina Romero · Cambridge, US
• Hanh Nho Nguyen · North Palm Beach, US
• Holly L. Deak · Brookline, US

Key dates

• Filing date: May 9, 2005
• Grant date: Feb 1, 2011
• Expiry date: Jun 25, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to chemical compounds having a general formula Iwherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.