Amide addition reaction
US7880011B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jul 15, 2008 |
| Grant date | Feb 1, 2011 |
| Priority date | — |
| Expiry date | Jul 15, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/127
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of making a compound of formula IIcomprising the reaction of a compound of formula RCONH2 with a compound of formula IIIR being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base.The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.