Compositions and systems for forming crosslinked biomaterials and methods of preparation of use

US7883693B2 · kind B2 · utility

Assignee

• Angiodevice International GmbH · CH

Inventors

• Louis C. Sehl · Redwood City, US
• Olof Mikael Trollsas · San Jose, US
• Donald G. Wallace · Menlo Park, US
• David Toman · Atherton, US
• Frank DeLustro · Belmont, US
• Jacqueline A. Schroeder · Redwood City, US
• George H. Chu · Sunnyvale, US

Key dates

• Filing date: Jan 31, 2006
• Grant date: Feb 8, 2011
• Expiry date: Aug 24, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2650/50
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.