Recombinant dimeric and heterodimeric proteins comprising amino acids 193 to 252 of the β chain of the human C4BP protein

US7884190B2 · kind B2 · utility

Assignee

• UNIVERSITÉ DE REIMS CHAMPAGNE-ARDENNE · FR

Inventors

• Jacques Cohen · New York, US
• Stéphane Oudin · Strasbourg, FR
• Xavier Dervillez · Wincheringen, DE
• Annelise Gimenez · Châlons-en-Champagne, FR
• Beatrice Donvito · Reims, FR
• Marcelle Tonye-Libyh · Reims, FR

Key dates

• Filing date: Oct 19, 2006
• Grant date: Feb 8, 2011
• Expiry date: Dec 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for preparing recombinant dimeric proteins using a nucleic acid coding for the C-terminal fragment of the C4BP protein β chain including amino acid residues 193 to 252 or a functional variant of the fragment, wherein the fragment enables covalent bonding of the heterologous polypeptides to which it is fused. Dimeric proteins obtained by means of the method and cells for carrying out the method are also described.